CUBIC

Target-oriented prioritization: targeted selection strategy by integrating organismal and molecular traits through predictive analytics in breeding

Genomic prediction in crop breeding is hindered by modeling on limited phenotypic traits. We propose an integrative multi-trait breeding strategy via machine learning algorithm, target-oriented prioritization (TOP). Using a large hybrid maize …

The genetic mechanism of heterosis utilization in maize improvement

Background: In maize hybrid breeding, complementary pools of parental lines with reshuffled genetic variants are established for superior hybrid performance. To comprehensively decipher the genetics of heterosis, we present a new design of multiple …

CUBIC: an atlas of genetic architecture promises directed maize improvement

Background: Identifying genotype-phenotype links and causative genes from quantitative trait loci (QTL) is challenging for complex agronomically important traits. To accelerate maize gene discovery and breeding, we present the Complete-diallel design …

MaizeCUBIC: a comprehensive variation database for a maize synthetic population

MaizeCUBIC is a free database that describes genomic variations, gene expression, phenotypes and quantitative trait locus (QTLs) for a maize CUBIC population (24 founders and 1404 inbred offspring). The database not only includes information for over …